Journal
NATURE MEDICINE
Volume 17, Issue 11, Pages 1359-1370Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2537
Keywords
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Funding
- US National Institutes of Health [R37 CA50286, R01 CA95262, R01 CA45726, P01 HL57900, R01 HL103956]
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As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. The tumor microenvironment comprises numerous signaling molecules and pathways that influence the angiogenic response. Understanding how these components functionally interact as angiogenic stimuli or as repressors and how mechanisms of resistance arise is required for the identification of new therapeutic strategies. Achieving a durable and efficient antiangiogenic response will require approaches to simultaneously or sequentially target multiple aspects of the tumor microenvironment.
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