Journal
NATURE MEDICINE
Volume 17, Issue 12, Pages 1680-U202Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2555
Keywords
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Funding
- US National Institutes of Health [R01HL076398, R01HL093717, R01HL108229-01A1]
- Center for Integration of Medicine and Innovative Technology [DAMD17-02-2-0006]
- American Heart Association [0830352N]
- Howard Hughes Medical Institute
- Cardio Vascular Research Foundation (CVRF)
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Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.
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