Journal
NATURE MEDICINE
Volume 16, Issue 10, Pages 1117-1119Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2233
Keywords
-
Funding
- US National Institutes of Health [R01HD038653, R01AI33292, R01AI052039]
- Elizabeth Glaser Pediatric AIDS Foundation
Ask authors/readers for more resources
Maternal HIV-1-specific antibodies are efficiently transferred to newborns, but their role in disease control is unknown. We administered neutralizing IgG, including the human neutralizing monoclonal IgG1b12, at levels insufficient to block infection, to six newborn macaques before oral challenge with simian-HIV strain SF162P3 (SHIVSF162P3). All of the macaques rapidly developed neutralizing antibodies and had significantly reduced plasma viremia for six months. These studies support the use of neutralizing antibodies in enhancing B cell responses and viral control in perinatal settings.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available