Journal
NATURE MEDICINE
Volume 16, Issue 6, Pages 662-664Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2145
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Funding
- Intramural NIH HHS [Z01 DE000695-09] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000558, ZIADE000695, ZIADE000551] Funding Source: NIH RePORTER
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A key step in gene therapy is the efficient transfer of genes in a cell type- and tissue-specific manner. To better understand the mechanism of adeno-associated virus serotype 6 (AAV6) transduction, we used comparative gene analysis (CGA) combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. Subsequent experiments suggested that EGFR is necessary for vector internalization and probably functions as a co-receptor for AAV6.
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