Journal
NATURE MEDICINE
Volume 16, Issue 12, Pages 1396-1399Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2264
Keywords
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Funding
- Spanish MICINN [BFU2008-04425, BFU2007-61855, SAF2008-00529, SAF2008-01004, CSD2007-00023]
- Fundacion de Investigacion Oftalmologica, Instituto de Oftalmologia Fernandez-Vega
- FONDECYT [1100983]
- Fundacion M. C.-Masadeu-Peterson
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Basal tearing is crucial to maintaining ocular surface wetness. Corneal cold thermoreceptors sense small oscillations in ambient temperature and change their discharge accordingly. Deletion of the cold-transducing ion channel Transient receptor potential cation channel subfamily M member 8 (TRPM8) in mice abrogates cold responsiveness and reduces basal tearing without affecting nociceptor-mediated irritative tearing. Warming of the cornea in humans also decreases tearing rate. These findings indicate that TRPM8-dependent impulse activity in corneal cold receptors contributes to regulating basal tear flow. (C) 2010 Nature America, Inc. All rights reserved.
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