Journal
NATURE MEDICINE
Volume 15, Issue 11, Pages 1327-U130Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.2032
Keywords
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Funding
- US National Cancer Institute [1U54CA119367, N44CM-2009-00011]
- US National Science Foundation [ECCS-0801385-000]
- US Defense Threat Reduction Agency [HDTRA1-07-1-0030-P00005]
- US Defense Advanced Research Projects Agency/Navy [N00014-02-1-0807]
- NCI ICMIC [P50 CA114747]
- US Department of Veterans Affairs Merit Review [B4872]
- Canary Foundation
- The National Semiconductor Corporation
- Stanford Medical School Medical Scientist Training Program
- National Science Foundation
- Denmark-American Foundation
- Lundbeck Foundation
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [0801385] Funding Source: National Science Foundation
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Advances in biosensor technologies for in vitro diagnostics have the potential to transform the practice of medicine. Despite considerable work in the biosensor field, there is still no general sensing platform that can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical samples (for example, serum, urine, cell lysates or saliva) with high sensitivity and large linear dynamic range. A major limitation confounding other technologies is signal distortion that occurs in various matrices due to heterogeneity in ionic strength, pH, temperature and autofluorescence. Here we present a magnetic nanosensor technology that is matrix insensitive yet still capable of rapid, multiplex protein detection with resolution down to attomolar concentrations and extensive linear dynamic range. The matrix insensitivity of our platform to various media demonstrates that our magnetic nanosensor technology can be directly applied to a variety of settings such as molecular biology, clinical diagnostics and biodefense.
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