Journal
NATURE MEDICINE
Volume 15, Issue 4, Pages 377-379Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.1940
Keywords
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Funding
- National Institutes of Health [R03NS57635, R24HD050845]
- Klingel Family Foundation
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Amyloid-beta (A beta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of A beta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.
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