Journal
NATURE MEDICINE
Volume 15, Issue 1, Pages 31-33Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.1902
Keywords
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Funding
- Swiss National Science Foundation [32-116106]
- Swiss Cancer League [KLS-01832-02-2006]
- Krebsliga Basel [8/05]
- Roche Research Foundation
- Novartis Research Foundation
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Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in human hepatoma cells. Our analysis of liver biopsies from subjects with chronic hepatitis C (CHC) undergoing IFN therapy revealed no correlation of miR-122 expression with viral load and markedly decreased pretreatment miR-122 levels in subjects who had no virological response during later IFN therapy; other investigated miRNAs showed only limited changes. These data have implications for the prospect of targeting miRNAs for CHC therapy.
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