Journal
NATURE MEDICINE
Volume 14, Issue 8, Pages 869-874Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.1711
Keywords
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Funding
- NCI NIH HHS [U54 CA119349, U54 CA119349-040003] Funding Source: Medline
- NHLBI NIH HHS [U01 HL080731-04, U01 HL080731] Funding Source: Medline
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Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.
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