Journal
NATURE MEDICINE
Volume 14, Issue 3, Pages 255-257Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1730
Keywords
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Funding
- NCI NIH HHS [P01 CA080124, P01-CA80124, R01 CA096915, R01-CA96915] Funding Source: Medline
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Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
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