Journal
NATURE MEDICINE
Volume 14, Issue 7, Pages 783-788Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1724
Keywords
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [U54 CA119347-03, U54 CA119347, R24 CA92865, P50 CA86306, P50 CA086306-10, R24 CA092865, 5U54 CA119347, P50 CA086306] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008042-23, T32 GM008042, T32 GM08042] Funding Source: Medline
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Monitoring immune function with molecular imaging could have a considerable impact on the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron emission tomography ( PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [F-18]FAC (1-(2'-deoxy-2'[F-18] fluoroarabinofuranosyl) cytosine) by differential screening as a new PET probe for the deoxyribonucleotide salvage pathway. [F-18]FAC enabled visualization of lymphoid organs and was sensitive to localized immune activation in a mouse model of antitumor immunity. [F-18] FAC microPET also detected early changes in lymphoid mass in systemic autoimmunity and allowed evaluation of immunosuppressive therapy. These data support the use of [F-18]FAC PET for immune monitoring and suggest a wide range of clinical applications in immune disorders and in certain types of cancer.
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