Journal
NATURE MATERIALS
Volume 10, Issue 11, Pages 877-883Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT3108
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Funding
- NRL (National Research Laboratory)
- Korea Science and Engineering Foundation (KOSEF), Republic of Korea [20110020455]
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [R11-2008-044-02002-0]
- Korea Research and Engineering Foundation (KOSEF)
- Korea government (KRF) [KRF-2008-220-D00133]
- National Research Foundation of Korea [R11-2008-044-02002-0, 2008-220-D00133, 220-2008-1-D00133, 2008-0061860] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Heterotypic functional materials with compositional and topographical properties that vary spatiotemporally on the micro- or nanoscale are common in nature. However, fabricating such complex materials in the laboratory remains challenging. Here we describe a method to continuously create microfibres with tunable morphological, structural and chemical features using a microfluidic system consisting of a digital, programmable flow control that mimics the silk-spinning process of spiders. With this method we fabricated hydrogel microfibres coded with varying chemical composition and topography along the fibre, including gas micro- bubbles as well as nanoporous spindle-knots and joints that enabled directional water collection. We also explored the potential use of the coded microfibres for tissue engineering applications by creating multifunctional microfibres with a spatially controlled co-culture of encapsulated cells.
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