Journal
NATURE MATERIALS
Volume 9, Issue 9, Pages 745-749Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT2815
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Funding
- Korea government (MEST) [2010-0017860, 2009-0082694]
- Ministry of Knowledge Economy
- Korea Institute of Industrial Technology(KITECH) [10030573] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0017860, 2009-0082694] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Encoded particles have a demonstrated value for multiplexed high-throughput bioassays such as drug discovery and clinical diagnostics(1,2). In diverse samples, the ability to use a large number of distinct identification codes on assay particles is important to increase throughput(3). Proper handling schemes are also needed to readout these codes on free-floating probe microparticles. Here we create vivid, free-floating structural coloured particles with multi-axis rotational control using a colour-tunable magnetic material and a new printing method(4). Our colour-barcoded magnetic microparticles offer a coding capacity easily into the billions with distinct magnetic handling capabilities including active positioning for code readouts and active stirring for improved reaction kinetics in microscale environments(5). A DNA hybridization assay is done using the colour-barcoded magnetic microparticles to demonstrate multiplexing capabilities.
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