Journal
NATURE MATERIALS
Volume 9, Issue 2, Pages 159-164Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMAT2606
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Funding
- National Science Foundation [DMR-0747756]
- NSF MRSEC at UMass [DMR-0820506]
- NSF [BBS-8714235]
- Korean Research Foundation [KRF-2008-357-D00079]
- National Research Foundation of Korea [2008-357-D00079] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820506] Funding Source: National Science Foundation
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Surfaces with physicochemical properties that can be modulated using external stimuli offer great promise for designing responsive or adaptive materials. Here, we describe biocompatible dynamic scaffolds based on thin hydrogel coatings that reversibly hide and display surface chemical patterns in response to temperature changes. At room temperature, the gel absorbs water, triggering an elastic creasing instability that sequesters functionalized regions within tight folds in the surface. Deswelling at similar to 37 degrees C causes the gel surface to unfold, thereby regenerating the biomolecular patterns. Crease positions are directed by topographic features on the underlying substrate, and are translated into two-dimensional micrometre-scale surface chemical patterns through selective deposition of biochemically functionalized polyelectrolytes. We demonstrate specific applications of these dynamic scaffolds-selective capture, sequestration and release of micrometre-sized beads, tunable activity of surface-immobilized enzymes and reversible encapsulation of adherent cells-which offer promise for incorporation within lab-on-a-chip devices or as dynamic substrates for cellular biology.
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