Journal
NATURE IMMUNOLOGY
Volume 15, Issue 12, Pages 1152-1161Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3025
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Funding
- US National Institutes of Health [R01 AI030048, R01 AI084887]
- Merieux Foundation
- Crohn's and Colitis Foundation
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The importance of autophagy in the generation of memory CD8(+) T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8(+) T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8(+) T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy.
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