Journal
NATURE IMMUNOLOGY
Volume 15, Issue 9, Pages 790-797Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2959
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Funding
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicate
- Aix-Marseille Universite
- French National Infrastructure for Mouse Phenogenomics (PHENOMIN)
- Agence Nationale de Recherche
- European Research Council
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The activation of T cells mediated by the T cell antigen receptor (TCR) requires the interaction of dozens of proteins, and its malfunction has pathological consequences. Our major focus is on new developments in the systems-level understanding of the TCR signal-transduction network. To make sense of the formidable complexity of this network, we argue that 'fine-grained' methods are needed to assess the relationships among a few components that interact on a nanometric scale, and those should be integrated with high-throughput '-omic' approaches that simultaneously capture large numbers of parameters. We illustrate the utility of this integrative approach with the transmembrane signaling protein Lat, which is a key signaling hub of the TCR signal-transduction network, as a connecting thread.
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