Journal
NATURE IMMUNOLOGY
Volume 15, Issue 6, Pages 533-534Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2893
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The colonization of the colon with commensal microflora drives the induction and population expansion of regulatory T cells, an immunological adaption needed to prevent mucosal inflammation. The epigenetic modifier Uhrf1 acts as a key molecular mediator of such expansion and the establishment of a harmonious mucosal environment.
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