Journal
NATURE IMMUNOLOGY
Volume 14, Issue 12, Pages 1212-1218Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2762
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Funding
- Core Research for Evolutional Science and Technology Program of the Japan Science and Technology Agency
- Japanese Ministry of Education, Culture, Sports, Science and Technology [23790534, 25460363]
- Senri Life Science Foundation
- RIKEN
- Grants-in-Aid for Scientific Research [23790534, 24113516, 25293118, 25460363, 24659151] Funding Source: KAKEN
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PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment.
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