Journal
NATURE IMMUNOLOGY
Volume 14, Issue 6, Pages 603-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2606
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Funding
- Swiss Vaccine Research Institute
- Swiss National Science Foundation [CRSII3_141879]
- Swiss National Science Foundation (SNF) [CRSII3_141879] Funding Source: Swiss National Science Foundation (SNF)
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During chronic infection, pathogen-specific CD8(+) T cells upregulate expression of molecules such as the inhibitory surface receptor PD-1, have diminished cytokine production and are thought to undergo terminal differentiation into exhausted cells. Here we found that T cells with memory-like properties were generated during chronic infection. After transfer into naive mice, these cells robustly proliferated and controlled a viral infection. The reexpanded T cell populations continued to have the exhausted phenotype they acquired during the chronic infection. Thus, the cells underwent a form of differentiation that was stably transmitted to daughter cells. We therefore propose that during persistent infection, effector T cells stably differentiate into a state that is optimized to limit viral replication without causing overwhelming immunological pathology.
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