Journal
NATURE IMMUNOLOGY
Volume 14, Issue 4, Pages 372-379Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2552
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Funding
- European Mouse Mutant Archive
- European Union
- Medical Research Council UK [U117512792]
- Deutsche Forschungsgemeinschaft [TU 316/1-1]
- Boehringer Ingelheim Fonds
- Medical Research Council [MC_U117512792] Funding Source: researchfish
- MRC [MC_U117512792] Funding Source: UKRI
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Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the T(H)17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such T(H)17 cells acquired a follicular helper T cell (T-FH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that T(H)17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.
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