Journal
NATURE IMMUNOLOGY
Volume 14, Issue 9, Pages 917-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/ni.2670
Keywords
-
Categories
Funding
- National Institute of Allergy and Infectious Diseases [R01-AI084884, U24 AI082660, T32-AI007061]
- National Institute of Arthritis, Musculoskeletal and Skin Diseases [K01-AR051367]
- National Institute of Diabetes and Digestive and Kidney Diseases [F32-DK097891]
- Lupus Research Institute
- Alliance for Lupus Research
- American Society of Nephrology
Ask authors/readers for more resources
The clearance of apoptotic cells is critical for the control of tissue homeostasis; however, the full range of receptors on phagocytes responsible for the recognition of apoptotic cells remains to be identified. Here we found that dendritic cells (DCs), macrophages and endothelial cells used the scavenger receptor SCARF1 to recognize and engulf apoptotic cells via the complement component C1q. Loss of SCARF1 impaired the uptake of apoptotic cells. Consequently, in SCARF1-deficient mice, dying cells accumulated in tissues, which led to a lupus-like disease, with the spontaneous generation of autoantibodies to DNA-containing antigens, activation of cells of the immune system, dermatitis and nephritis. The discovery of such interactions of SCARF1 with C1q and apoptotic cells provides insight into the molecular mechanisms involved in the maintenance of tolerance and prevention of autoimmune disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available