Journal
NATURE IMMUNOLOGY
Volume 13, Issue 10, Pages 1010-1019Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2402
Keywords
-
Categories
Funding
- US National Institutes of Health [R37 AI034206]
- Howard Hughes Medical Institute
- Arthritis Foundation postdoctoral fellowship
- Cancer Research Institute
- National Institutes of Health Medical Scientist Training Program grant [GM07739]
- National Institute of Neurological Disorders and Stroke [1F31NS073203-01]
- National Institutes of Health [DK091968]
- Medical Scientist Training Program [GM07739]
Ask authors/readers for more resources
The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (T-reg cells). To gain insights into the molecular mechanisms of Foxp3-mediated gene expression, we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multiprotein complexes of 400-800 kDa or larger and identified 361 associated proteins, similar to 30% of which were transcription related. Foxp3 directly regulated expression of a large proportion of the genes encoding its cofactors. Some transcription factor partners of Foxp3 facilitated its expression. Functional analysis of the cooperation of Foxp3 with one such partner, GATA-3, provided additional evidence for a network of transcriptional regulation afforded by Foxp3 and its associates to control distinct aspects of T-reg cell biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available