Journal
NATURE IMMUNOLOGY
Volume 13, Issue 10, Pages 1000-1009Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2395
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Funding
- National Institute of Allergy and Infectious Diseases of the US National Institutes of Health [R24 AI072073, R01 AI068129, T32AI060537, T32AI060536, AI072117]
- American Cancer Society
- Canadian Institutes of Health Research
- Searle Scholars Program
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Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8(+) T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.
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