Journal
NATURE IMMUNOLOGY
Volume 13, Issue 7, Pages 628-630Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2345
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The cellular mechanism by which the cytokine TGF-beta maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-b restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.
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