Journal
NATURE IMMUNOLOGY
Volume 13, Issue 8, Pages 719-720Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2377
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The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the T(H)17 subset.
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