Journal
NATURE IMMUNOLOGY
Volume 13, Issue 5, Pages 439-447Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2246
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Canada Research Chairs program
- Howard Hughes Medical Institute
Ask authors/readers for more resources
Lymphocyte activation must be tightly regulated to ensure sufficient immunity to pathogens and prevent autoimmunity. Protein tyrosine phosphatases (PTPs) serve critical roles in this regulation by controlling the functions of key receptors and intracellular signaling molecules in lymphocytes. In some cases, PTPs inhibit lymphocyte activation, whereas in others they promote it. Here we discuss recent progress in elucidating the roles and mechanisms of action of PTPs in lymphocyte activation. We also review the accumulating evidence that genetic alterations in PTPs are involved in human autoimmunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available