Journal
NATURE IMMUNOLOGY
Volume 13, Issue 1, Pages 44-U64Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2172
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Funding
- Trudeau Institute
- US National Institutes of Health [AI028973-23, AI063428-06, T32 A1049823-10]
- Royal Society
- Wellcome Trust [084923/B/08/Z]
- Medical Research Council
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI028973, T32AI049823, R01AI076479, R37AI028973, R56AI063428, R01AI063428] Funding Source: NIH RePORTER
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Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.
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