Journal
NATURE IMMUNOLOGY
Volume 12, Issue 6, Pages 467-471Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2038
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Funding
- NCI NIH HHS [T32 CA009138] Funding Source: Medline
- NIAID NIH HHS [R01 AI039614] Funding Source: Medline
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Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the T(H)2 cell, T(H)17 helper T cell, follicular helper T cell (T-FH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process.
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