Journal
NATURE IMMUNOLOGY
Volume 12, Issue 2, Pages 178-U95Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1983
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Funding
- National Natural Science Foundation of China [30623003, 31030029, 30721065, 30801011, 90713044, 30870126, 30950002]
- Chinese Academy of Sciences [KSCX2-YW-R-161, KSCX2-YW-R-169]
- Technology Commission of Shanghai Municipality [08DZ2291703, 088014199, 08431903004]
- National 973 key project [2007CB512404]
- National 863 project [2006AA02A247]
- EU [SP5B-CT-2006-044161]
- China National Science and Technology [2008ZX10002-014, 2008ZX10004-002, 2009ZX10004-105, 2009ZX10004-016]
- China National Ministry of Science and Technology [20072714]
- Shanghai Pasteur Health Research Foundation [SPHRF2008001, SPHRF2009001]
- E-institutes of the Shanghai Universities Immunology Division
- Li Kha Shing Foundation
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Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression.
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