Journal
NATURE IMMUNOLOGY
Volume 12, Issue 9, Pages 809-UPublisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2088
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In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-beta (TGF-beta), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.
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