Journal
NATURE IMMUNOLOGY
Volume 12, Issue 6, Pages 472-477Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2019
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Funding
- Pfizer Australia
- Australian Research Council
- National Health and Medical Research Council of Australia
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Humoral immunity requires interaction between specialized populations of B cells and CD4(+) T cells, called follicular helper T cells (T-FH cells), in the germinal center (GC) to produce memory B cells and long-lived plasma cells. Molecular crosstalk between GC B cells and T-FH cells influences the survival, proliferation and differentiation of each cell type. This pairing of GC B cells and T-FH cells also occurs at the transcriptional level as the Bcl-6-IRF4-Blimp-1 axis, which is crucial for B cell differentiation, is also essential for the T-FH cell identity. Less is known about the memory B cells that arise from the GC pool, as they seem to be distinctly 'programmed' on the basis of their antigen receptor affinity to enter the long-lived memory pool.
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