Journal
NATURE IMMUNOLOGY
Volume 12, Issue 12, Pages 1135-1137Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.2162
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Natural killer T cells (NKT cells) recognize lipid-based antigens presented by CD1d. The mammalian glycolipid beta-glucosylceramide, a ubiquitous self antigen for NKT cells, is upregulated by microbial danger signals, which leads to activation of NKT cells in the absence of foreign glycolipid antigen.
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