Journal
NATURE IMMUNOLOGY
Volume 11, Issue 4, Pages 350-U32Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1850
Keywords
-
Categories
Funding
- NIAID NIH HHS [R01 AI024742-24, AI024742, R01 AI024742] Funding Source: Medline
- NIDDK NIH HHS [DK058177, R01 DK058177, P60 DK020579-309002, P60DK20579, R01 DK058177-11, P30 DK020579, P60 DK020579] Funding Source: Medline
Ask authors/readers for more resources
In addition to the genetic framework, there are two other critical requirements for the development of tissue-specific autoimmune disease. First, autoreactive T cells need to escape thymic negative selection. Second, they need to find suitable conditions for autoantigen presentation and activation in the target tissue. We show here that these two conditions are fulfilled in diabetic mice of the nonobese diabetic (NOD) strain. A set of autoreactive CD4(+) T cells specific for an insulin peptide, with the noteworthy feature of not recognizing the insulin protein when processed by antigen-presenting cells (APCs), escaped thymic control, participated in diabetes and caused disease. Moreover, APCs in close contact with beta cells in the islets of Langerhans bore vesicles with the antigenic insulin peptides and activated peptide-specific T cells. Our findings may be relevant for other cases of endocrine autoimmunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available