Journal
NATURE IMMUNOLOGY
Volume 11, Issue 7, Pages 585-U52Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1889
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Funding
- Canadian Institutes for Health Research
- Stem Cell Network of Canadian National Centres of Excellence
- Canadian Cancer Society Research Institute
- Terry Fox Foundation
- Genome Canada through the Ontario Genomics Institute
- Ontario Institute for Cancer Research
- province of Ontario
- Leukemia and Lymphoma Society
- Canada Research
- Ontario Ministry of Health and Long Term Care
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The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model in the mouse has been questioned; however, little is known about the lineage potential of human progenitors. Here we provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. Human multilymphoid progenitors, identified as a distinct population of Thy-1(neg-lo)CD45RA(+) cells in the CD34(+)CD38(-) stem cell compartment, gave rise to all lymphoid cell types, as well as monocytes, macrophages and dendritic cells, which indicated that these myeloid lineages arise in early lymphoid lineage specification. Thus, as in the mouse, human hematopoiesis does not follow a rigid model of myeloid-lymphoid segregation.
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