Journal
NATURE IMMUNOLOGY
Volume 11, Issue 3, Pages 216-U4Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1838
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Funding
- University of Rochester and the National Institutes of Health [AI61511, HL69409, AI06856]
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The question of which dendritic cells (DCs) respond to pulmonary antigens and cross-prime CD8(+) T cells remains controversial. We show here that influenza-specific CD8(+) T cell priming was controlled by different DCs at different times after infection. Whereas early priming was controlled by both CD103(+)CD11b(lo) and CD103-CD11b(hi) DCs, CD103-CD11b(hi) DCs dominated antigen presentation at the peak of infection. Moreover, CD103-CD11b(hi) DCs captured exogenous antigens in the lungs and directly cross-primed CD8(+) T cells in the draining lymph nodes without transferring antigen to CD8(alpha)(+) DCs. Finally, we show that CD103-CD11b(hi) DCs were the only DCs to express CD70 after influenza infection and that CD70 expression on CD103-CD11b(hi) DCs licensed them to expand CD8(+) T cell populations responding to both influenza and exogenous ovalbumin.
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