Journal
NATURE IMMUNOLOGY
Volume 11, Issue 8, Pages 674-680Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1899
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI076427-02, R01 AI076427] Funding Source: Medline
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As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.
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