Journal
NATURE IMMUNOLOGY
Volume 11, Issue 1, Pages 7-13Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1818
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Funding
- Ministry of Education, Sports and Culture
- Ministry of Human Welfare of Japan
- King Gustav V's 80-Year Foundation
- Swedish Society of Medical Research
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Immunological self tolerance is maintained at least in part by regulatory T (T-reg) cells that actively and dominantly control potentially hazardous self-reactive T cells in the periphery. Antigens that stimulate self-reactive T cells may also activate natural T-reg cells, thereby maintaining dominant self tolerance. Conversely, genetic anomalies or environmental agents that specifically or predominantly affect T-reg cells cause or predispose to autoimmunity. With recent advances in our understanding of T-reg cell development in the thymus and periphery and the molecular mechanism of T-reg cell-mediated suppression, new ways of treating immunological diseases by targeting T-reg cells at the cellular and molecular levels are envisaged.
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