Journal
NATURE IMMUNOLOGY
Volume 10, Issue 5, Pages 524-530Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1718
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Funding
- Australian National Health and Medical Research Council
- Howard Hughes Medical Institute
- German Research Foundation [GE1666/1-1]
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Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.
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