Journal
NATURE IMMUNOLOGY
Volume 10, Issue 2, Pages 203-213Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1692
Keywords
-
Categories
Funding
- Netherlands Organisation for Scientific Research [NWO 917-46-367, 912-04-025]
- AIDS Foundation [2007036]
- Dutch Asthma Foundation [3.2.03.39]
Ask authors/readers for more resources
The C-type lectin dectin-1 activates the transcription factor NF-kappa B through a Syk kinase-dependent signaling pathway to induce antifungal immunity. Here we show that dectin- 1 expressed on human dendritic cells activates not only the Syk-dependent canonical NF-kappa B subunits p65 and c-Rel, but also the noncanonical NF-kappa B subunit RelB. Dectin-1, when stimulated by the beta-glucan curdlan or by Candida albicans, induced a second signaling pathway mediated by the serine-threonine kinase Raf-1, which integrated with the Syk pathway at the point of NF-kappa B activation. Raf-1 antagonized Syk-induced RelB activation by promoting sequestration of RelB into inactive p65-RelB dimers, thereby altering T helper cell differentiation. Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available