4.7 Article

From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce TH1 development

Journal

NATURE IMMUNOLOGY
Volume 10, Issue 9, Pages 929-932

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ni0909-929

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Funding

  1. MRC [MC_U117565642] Funding Source: UKRI
  2. Medical Research Council [MC_U117565642] Funding Source: researchfish
  3. Medical Research Council [MC_U117565642] Funding Source: Medline

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The authors recount their discovery of how pathogen-induced interleukin 12 production leads to T(H)1 T cell polarization. Simultaneously they discovered the suppressive cytokine interleukin 10 inhibits antigen-presenting cells, thus regulating development of T(H)1 cells.

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