Journal
NATURE IMMUNOLOGY
Volume 10, Issue 9, Pages 973-U62Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1763
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Funding
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Howard Hughes Medical Institute
- Institut National de la Sante et de la Recherche Medicale
- Agence Nationale de la Recherche
- Ligue Nationale Contre le Cancer-Ile de France
- Clinical Research Institute of Montreal
- Canada Research Chair Program
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The adaptors SAP, EAT-2 and ERT are specific to cells of the immune system and belong to the SAP family. All three are expressed in natural killer (NK) cells. Here we examined the global function of the SAP family using mice lacking SAP, EAT-2 and ERT. These adaptors acted together in a mechanism that was essential for the elimination of hematopoietic but not nonhematopoietic cells by NK cells. This function was mediated by many receptors of the SLAM family on NK cells that were engaged by ligands found solely on hematopoietic cells. In the absence of SAP-related adaptors, SLAM receptors lost their activating function and became inhibitory receptors that repressed other activating receptors, such as NKG2D. Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells.
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