Journal
NATURE IMMUNOLOGY
Volume 10, Issue 12, Pages 1245-U3Publisher
NATURE PORTFOLIO
DOI: 10.1038/ni.1813
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Funding
- National Health and Medical Research Council of Australia
- US National Institutes of Health [AI51321]
- Howard Hughes Medical Institute
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Interleukin 17 (IL-17)-producing helper T cells (T-H-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry. The mechanism of complex formation was unique for cytokines and involved the engagement of IL-17 by two fibronectin-type domains of IL-17RA in a groove between the IL-17 homodimer interface. Binding of the first receptor to the IL-17 cytokines modulated the affinity and specificity of the second receptor-binding event, thereby promoting heterodimeric versus homodimeric complex formation. IL-17RA used a common recognition strategy to bind to several members of the IL-17 family, which allows it to potentially act as a shared receptor in multiple different signaling complexes.
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