Journal
NATURE IMMUNOLOGY
Volume 10, Issue 3, Pages 241-247Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1703
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Funding
- National Institutes of Health
- Arthritis Foundation
- Jung-Stiftung fur Wissenschaft und Forschung
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI064748, R01AI063331] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR052756] Funding Source: NIH RePORTER
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The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1 beta (IL-1 beta) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC are critical components of the inflammasome that link microbial and endogenous 'danger' signals to caspase-1 activation. Several diseases are associated with dysregulated activation of caspase-1 and secretion of IL-1 beta. Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention.
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