Journal
NATURE IMMUNOLOGY
Volume 11, Issue 1, Pages 21-27Publisher
NATURE PORTFOLIO
DOI: 10.1038/ni.1817
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Funding
- US National Institutes of Health [P01 AI35296, R01 AI080764]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI080764, P01AI035296] Funding Source: NIH RePORTER
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The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.
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