Journal
NATURE IMMUNOLOGY
Volume 11, Issue 1, Pages 3-6Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1833
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Funding
- US National Institutes of Health [DK059658, DK060027, AI051530, AI56299]
- Juvenile Diabetes Research Foundation [4-2007-1057]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI051530, R01AI051530, P01AI056299] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK059658, R01DK060027, R37DK060027] Funding Source: NIH RePORTER
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Immunological tolerance guards against spurious immune responses to body constituents. Tolerance encompasses a network of mechanisms: central and peripheral, cell-autonomous and cell-interactive. Our understanding of these mechanisms has improved greatly over recent years, often reflecting new insights into the processes underlying particular autoimmune diseases. Yet it is possible that important tolerance mechanisms remain to be discovered, perhaps an explanation for the so-far disappointing clinical translation to the prevention and cure of autoimmune diseases.
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