Journal
NATURE IMMUNOLOGY
Volume 10, Issue 6, Pages 587-U48Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.1733
Keywords
-
Categories
Funding
- Ministero dell'Universita e della Ricerca of Italy
Ask authors/readers for more resources
Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers. Thus, this cell type-specific recognition pathway links lysosomal recognition of bacterial RNA with a robust, host-protective interferon response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available