Journal
NATURE IMMUNOLOGY
Volume 9, Issue 5, Pages 459-461Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0508-459
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Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.
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