Journal
NATURE IMMUNOLOGY
Volume 9, Issue 4, Pages 415-423Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1573
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01-GM57411, R01 GM057411, R01-GM23547, R01 GM023547, R01 GM057411-10, R01 GM023547-32] Funding Source: Medline
Ask authors/readers for more resources
The extracellular lysophospholipase D autotaxin (ATX) and its product, lysophosphatidic acid, have diverse functions in development and cancer, but little is known about their functions in the immune system. Here we found that ATX had high expression in the high endothelial venules of lymphoid organs and was secreted. Chemokine-activated lymphocytes expressed receptors with enhanced affinity for ATX, which provides a mechanism for targeting the secreted ATX to lymphocytes undergoing recruitment. Lysophosphatidic acid induced chemokinesis in T cells. Intravenous injection of enzymatically inactive ATX attenuated the homing of T cells to lymphoid tissues, probably through competition with endogenous ATX and exertion of a dominant negative effect. Our results support the idea of a new and general step in the homing cascade in which the ectoenzyme ATX facilitates the entry of lymphocytes into lymphoid organs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available