Journal
NATURE IMMUNOLOGY
Volume 9, Issue 4, Pages 343-345Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni0408-343
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TLR4 somehow manages to activate both MyD88- and TRIF-dependent signaling. According to Medzhitovc and colleagues, TLR4 engages MyD88 and TRIF sequentially at the cell surface and in endosomes, respectively, thereby providing access to distinct pools of signaling proteins.
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