Journal
NATURE IMMUNOLOGY
Volume 9, Issue 10, Pages 1105-1111Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.f.215
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Funding
- National Institutes of Health [AI057229]
- Howard Hughes Medical Institute
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI057229] Funding Source: NIH RePORTER
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T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor-mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for this synaptic secretion and have also shown that T cells release chemokines and certain inflammatory factors through a multidirectional pathway directed away from the synapse. Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule.
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